DOXORUBICIN-INDUCED PLATELET ACTIVATION AND CLEARANCE RELIEVED BY SALVIANOLIC ACID COMPOUND: NOVEL MECHANISM AND POTENTIAL THERAPY FOR CHEMOTHERAPY-ASSOCIATED THROMBOSIS AND THROMBOCYTOPENIA

Doxorubicin (Dox) is a widely utilized chemotherapeutic; however, it carries side effects, including drug-induced immune thrombocytopenia (DITP) and increased risk of venous thromboembolism (VTE).Currently, the mechanisms for Dox-associated DITP and VTE are poorly understood, and an effective inhibitor to relieve these complications remains to be d

Mechanics has been a central focus of physical biology in the past decade.In comparison, how cells manage their size is less understood.Here, we show that artificial a parameter central to both the physics and the physiology of the cell, its volume, depends on a mechano-osmotic coupling.We found that cells change their volume depending on the rate

Thrombosis and infection are 2 major complications associated with central venous catheters (CVCs), resulting in substantial mortality and morbidity.The concurrent long-term administration of antibiotics and anticoagulants to address these hair complications have been demonstrated to cause severe side effects such as antibiotic resistance and bleed

Recent research suggests that in some West German regions, single-family housing (SFH) neighbourhoods are prone to decay due to changed socio-economic and demographic trends.The question of whether similar demographic trends and implications for the SFH stock can be described for other West European countries such as Belgium, France, Netherlands an